SOWAHB polymorphisms affect thyroid cancer risk in the Chinese Han population

ABSTRACT

Objectives

This study aimed to detect the correlation between SOWAHB polymorphisms and Thyroid cancer (TC) risk in the Chinese Han population.

Methods

We genotyped SOWAHB variants in 510 TC patients and 509 controls using Agena MassARRAY. We assessed the association between SOWAHB polymorphisms and TC susceptibility, with the significant results evaluated through FPRP analysis. We predicted TC risk by the SNP-SNP interaction, analyzed by MDR.

Results

Carriers with rs2703129 CC had a lower probability of TC (codominant, recessive: p = 0.002), while subjects with rs1874564 AG had an increased risk of developing TC (codominant, recessive: p = 0.000, log-additive: p = 0.028). In subjects aged > 45 years, rs2703129 may reduce TC predisposition (codominant: p = 0.011, recessive: p = 0.007), but there was an increased association between rs1874564 and TC risk (codominant: p = 0.030, dominant: p = 0.047). Also, rs2703129 was associated with a lower risk of TC among males (codominant: p = 0.018, recessive: p = 0.013). Conversely, rs1874564 was associated with an increased risk of TC in females (codominant: p = 0.001, dominant: p = 0.003).

Conclusion

SOWAHB SNPs were related to the occurrence of TC, and rs2703129 may be a protective site for TC.

KEYWORDS:

• Thyroid cancer
• SOWAHB
• single nucleotide polymorphism
• correlation analysis
• Chinese Han population

Article highlights

• Thyroid cancer (TC) was the most common endocrine malignancy.

• The biological function of SOWAHB in the biology of TC remains obscure.

• Rs2703129 was associated with a decreased risk of TC.

• Rs1874564 may increase the risk of TC.

• The results provided a new biological perspective for the pathological interpretation of TC.

Abbreviations

TC: Thyroid cancer, SOWAHB: Sosondowah Ankyrin Repeat Domain Family Member B, FPRP: False-positive report probability, MDR: Multi-factor dimensionality reduction, SNPs: single nucleotide polymorphisms, MAF: minor allele frequency, HWE: Hardy-Weinberg Equilibrium, OR: odds ratio, 95% CI: 95% confidence interval.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Acknowledgments

We thank all participants in this study.

Data availability statement

The datasets used and analyzed in our current study are available from corresponding author for all reasonable request.

Authors’ contributions

M Zhang and J Liang completed the experiment, performed the manuscript and revised the manuscript. JH Han and WJ Zhang completed the software analysis. PP Wan, LT Yang and XF Zang revised the manuscript. TB Jin co-supervised the research and revised the manuscript. All the authors participated in the conception and design of the article and the interpretation of the relevant literature. All authors agree to be published in the journal.

Ethics statement

All participants have signed informed consent. And our study was approved by the Ethics Committee of Northwest University and the First Affiliated Hospital of Xi’an Jiaotong University. Consent to participate: The study was agreed by all the subjects.

Supplementary material

Supplemental data for this article can be accessed online at https://doi.org/10.1080/14737159.2024.2305183.

Additional information

Funding

This paper was not funded.