Antibiotics-associated pseudomembranous colitis: a disproportionality analysis of the US food and drug administration adverse event reporting system (FAERS) database

ABSTRACT

Background

Evaluating antibiotics most commonly associated with pseudomembranous colitis (PMC) based on the real-world data is of great significance.

Research design and methods

We used the data from FAERS to evaluate the potential association between antibiotics and PMC by disproportionality analyzes.

Results

Eighty-one antibiotics which met the three algorithms simultaneously were enrolled. There were 1683 reports of PMC associated with the enrolled antibiotics. In the top 24 antibiotics, cefoxitin, streptomycin, fosfomycin, and micafungin had a high risk of PMC, but there were few reports in the literature.

Conclusions

This study was of great significance for healthcare professionals to realize the potential PMC risks of antibiotics.

KEYWORDS:

• Pseudomembranous colitis
• antibiotic
• FAERS
• adverse event
• disproportionality analyzes

Declaration of interests

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Author contributions

J Chen, W Zhang and W Yu designed the analysis. J Chen and C Sun collected the data and performed the analysis. J Chen wrote the paper. W Zhang, C Sun and W Zhang revised the manuscript.

Additional information

Funding

This paper was not funded.