Umbilical cord blood and maternal visfatin (PBEF/NAMPT) concentrations in preterm birth with and without preterm premature rupture of membranes

Abstract

Objectives: The aim of the study is to investigate differences in visfatin concentrations between mothers with term and preterm birth (PTB) and between mothers who delivered within seven days and after more than seven days following admission for PTB/preterm premature rupture of membranes (PPROMs).

Methods: Maternal peripheral blood and cord blood were collected from 56 mothers with PTB (31 with PPROM) and 71 mothers with term delivery (three with PPROM).

Results: Maternal visfatin concentration was significantly higher for given gestational age in PTBs compared to term deliveries (p = .021) and also in mothers who delivered within seven days after admission for PTB or PPROM, compared to those who delivered after more than seven days (p = .027; p = .039). Cord blood visfatin concentration was found to be decreased in preterm compared to term infants (p = .007).

Conclusions: Visfatin in both maternal and fetal circulation may play an important role in the pathogenesis of PTB/PPROM and could be used to distinguish between women who will deliver in a short period of time after clinical presentation of PTB/PPROM and those who deliver later. Nevertheless, additional research is necessary in order to identify its direct involvement in PTB/PPROM.

Keywords:

• Visfatin
• PBEF
• NAMPT
• preterm birth
• preterm premature rupture of membranes

Acknowledgements

This research was financially supported by Masaryk University (CETOCOEN PLUS (CZ.02.1.01/0.0/0.0/15_003/0000469)) and the RECETOX Research Infrastructure (LM2015051 project of the Ministry of Education, Youth and Sports of the Czech Republic).

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This research was financially supported by Masaryk University (CETOCOEN PLUS (CZ.02.1.01/0.0/0.0/15_003/0000469)) and the RECETOX Research Infrastructure (LM2015051 project of the Ministry of Education, Youth and Sports of the Czech Republic).