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The Journal of Maternal-Fetal & Neonatal Medicine Volume 31, 2018 - Issue 18
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Original Article

Increase of neuronal injury markers Tau and neurofilament light proteins in umbilical blood after intrapartum asphyxia

Hanna Toorella Perinatal Center, Institute of Clinical Sciences, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden; View further author information
,
Henrik Zetterbergb Clinical Neurochemistry Laboratory, Mölndal, Sweden; ;c Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Mölndal, Sweden; ;d Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, UK; View further author information
,
Kaj Blennowb Clinical Neurochemistry Laboratory, Mölndal, Sweden; ;c Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Mölndal, Sweden; View further author information
,
Karin Sävmane Department of Pediatrics, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden; View further author information
&
Henrik Hagberga Perinatal Center, Institute of Clinical Sciences, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden; ;f Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King’s College London, St. Thomas’ Hospital, London, UKCorrespondence[email protected]
View further author information
Pages 2468-2472 | Received 20 Mar 2017, Accepted 17 Jun 2017, Published online: 09 Jul 2017
 
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Abstract

Aim: Compare the levels of the brain injury biomarkers Tau and neurofilament light protein (NFL) in cases of asphyxia with those in controls.

Materials and methods: We analyzed the neuronal proteins Tau and NFL in umbilical blood of 10 cases of severe-moderate intrapartum asphyxia and in 18 control cases.

Results: The levels of both Tau and neurofilament were significantly higher after asphyxia and it appeared to be a correlation between the levels of the biomarkers and the severity of the insult.

Discussion: Future studies are warranted to support or refute the value of Tau/NFLin clinical practice.

Conclusion: Fetal asphyxia remains a clinical problem resulting in life-long neurological disabilities. We urgently need more accurate early predictive markers to direct the clinician when to provide neuroprotective therapy.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

We gratefully acknowledge the support of the Department of Perinatal Imaging and Health and financial support from Welcome Trust [WT094823], the Swedish Medical Research Council [VR 2015-02493; 2013–2546], Governmental Grants to University Hospitals in Sweden [ALFGBG-426401, ALFGBG-441051], Action Medical Research, ERA-net [EU; VR 529-2014-7551], the Knut and Alice Wallenberg Foundation (HZ is a Wallenberg Academy Fellow), Hjärnfonden [Brain Foundation 2015-0004], the Leducq Foundation [DSRRP34404] and the Wilhelm and Martina Lundgren Foundation, to enable this study to be completed. In addition, the authors acknowledge financial support from the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Center Award to Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London and King’s College Hospital NHS Foundation Trust.

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