Current understanding of autoantibody against angiotensin II type 1 receptor in preeclampsia

Abstract

Preeclampsia (PE) remains a leading cause of fetal and maternal mortality. Angiotensin II type 1 receptor autoantibody (AT1-AA) is implicated in the dysregulation of the renin-angiotensin-aldosterone system. A strong relationship between AT1-AA and the occurrence and severity of PE has been confirmed in previous literature. Recent evidences suggested that AT1-AA was responsible for blood pressure elevation, reactive oxygen species synthesis, and inflammatory factors release and engaged in multiple signaling cascades. The inhibition of AT1-AA might be a potential therapeutic target in future days. Here we reviewed the current understanding of AT1-AA, aiming to provide clarity surrounding the role of AT1-AA in PE.

Keywords:

• AT1-AA
• pregnancy
• preeclampsia
• therapy targets

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by National Natural Science Foundation of China NO. 82071670 (Jinjun Liu), NO. 81972814 (Weiyi Feng), NO. 81771616 (Jinjun Liu), NO. 81471471 (Jinjun Liu) and NO. 81372379 (Weiyi Feng). Tkanks for Dr. Zhuo Zhao for his kind support and love during the whole writing.