Is real-time dynamic cervical shortening predictive of preterm birth?- A case control study

Abstract

Objectives

We aimed to assess the risk of preterm birth in those with real-time dynamic cervical shortening.

Methods

A retrospective matched case-control study. The study group comprised all women with dynamic cervical shortening (≥4 mm) noted from 24 to 34 weeks of gestation during 2010–2017 at a university hospital. Two control groups of women were established by matching the minimal and maximal cervical length measured, as well as age, parity, gestational age, history of spontaneous preterm birth, symptoms of preterm labor, and delivery year.

Results

Data from 339 women were analyzed, 113 with dynamic cervical shortening comprised the study group, and two groups with 113 women each, matched for the minimal and maximal cervical lengths measured comprised the control groups. Rates of spontaneous preterm birth rate at <37 weeks (32.7% vs. 15.9%; OR [95% CI]: 2.60 (1.36, 4.87), p = .004) and <35 weeks (15.9% vs. 5.3%; OR [95% CI]: 3.38 (1.29, 8.86), p = .013) were significantly higher among those with dynamic cervix than among the control group matched for the maximal cervical length, and comparable to the control group matched for the minimal cervical length. The negative predictive values of cervical length for preterm birth occurrence at various cutoff values were lower in those with dynamic cervix.

Conclusions

The minimal cervical length measured should be used to guide patient management when dynamic cervix is noted. In the setting of dynamic cervical change, the value of cervical length as a negative predictor of preterm birth is limited.

Keywords:

• Cervical length
• dynamic change
• cervix
• preterm delivery
• sonographic

Acknowledgements

Neta Gochman’s participation in this study was performed in fulfillment of the research requirements toward the MD degree. We thank Ms. Cindy Cohen for her editorial assistance.

Disclosure statement

The authors declare that they have nothing to disclose and that they have no financial or non-financial conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved in January 2018 by the Human Investigation Review Board of Hadassah Hebrew University Medical center (IRB approval number: HMO − 0636- 17).

Informed consent

Informed consent was not needed for this study due to its retrospective design.