Effects of two modalities of noninvasive ventilation on breathing pattern of very low birth weight preterm infants immediately after extubation: a quasi-experimental study

Abstract

Aim

The primary objective of this study was to investigate the effects of two modalities of noninvasive ventilation, continuous positive airway pressure-CPAP and non-synchronized nasal intermittent positive pressure ventilation-nsNIPPV, on breathing pattern of very low birth weight preterm infants immediately after extubation.

Methods

It was conducted a quasi-experimental study at a public university hospital. Infants with gestacional age ≤32 weeks and birth weight ≤1,500 g were randomized into the sequences, prior extubation: CPAP – nsNIPPV (1) or nsNIPPV – CPAP (2). Each preterm infant was studied for a period of 60 min in each ventilatory mode. Respiratory inductive plethysmography was used to assess breathing pattern. Inferential analysis was performed by repeated measures ANOVA or Friedman test.

Results

Eleven preterm infants were studied and a total of 7,564 respiratory cycles were analyzed. No significant differences were observed in any of the comparisons made for any of the breathing pattern variables (p > .05).

Conclusions

There was no significant difference on breathing pattern between CPAP and nsNIPPV of preterm infants after extubation.

Keywords:

• Continuous positive airway pressure
• CPAP
• non-synchronized nasal intermittent positive pressure ventilation
• nsNIPPV
• newborns

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The work was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Finance Code 001 and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), [Grant 309990/2017-3]; from Brazil. The funding sources had no role in the design, conduct or reporting of this study.