Do fetuin-A/apha2-Heremans Schmid-glycoprotein levels have an association with recurrent pregnancy loss?

Abstract

Objective

Fetuin-A is a hepatokine which is previously found related to fertility and pregnancy outcomes. We aimed to investigate if recurrent pregnancy loss (RPL) is associated with increased fetuin-A levels.

Materials and methods

Serum fetuin-A concentrations were measured and compared in 30 non-pregnant women with a history of unexplained recurrent miscarriage, 29 women who had a history of unexplained recurrent miscarriage and were admitted to our clinic due to miscarriage during the study period and 30 fertile women who have no history of miscarriage or any other pregnancy complications with at least two previous healthy children.

Results

The median serum fetuin-A levels of group I, II, and III were 59.45, 62.73, and 44.52, respectively (p=.065). Serum fetuin-A levels significantly increased in group II compared to group III (p=.011). No significant differences in the levels of fetuin-A of group I compared to either group II (p=.433) or group III (p=.268).

Conclusions

The etiology of RPL is still a subject that is not clarified. Fetuin-A levels may have a relationship with RPL.

Keywords:

• Fetuin-A
• recurrent pregnancy loss
• pregnancy
• habitual abortion
• apha2-Heremans Schmid-glycoprotein

Disclosure statement

No potential conflict of interest was reported by the author(s).