A potential role for olanzapine in the treatment of hyperemesis gravidarum

Abstract

Hyperemesis gravidarum is a rare but potentially serious complication of pregnancy. Some women with severe symptoms and possibly psychiatric comorbidities remain symptomatic despite the use of currently available treatments. Due to its favorable safety profile, antiemetic efficacy in other conditions, and 5-HT3 antagonism, olanzapine may be a potentially useful addition to the armamentarium for management of hyperemesis gravidarum resistant to standard- of-care treatment.

Keywords:

• Pregnancy
• nausea
• vomiting
• hyperemesis gravidarum
• treatment
• olanzapine
• safety

Acknowledgement

The authors did not receive support from any organization for the submitted work.

Author contributions

The first draft of the manuscript was written by Drs. Verinder Sharma and Alex Martin. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).