A new cerebroside from Gynura divaricata

Abstract

A new cerebroside (1) was isolated from the aerial parts of Gynura divaricata DC., along with five known compounds: kaempferol (2), kaempferol 3-O-glucoside (3), kaempferol 3-O-rhamnosyl(1 → 6)glucoside (4), β-sitosteryl glucoside-6′-O-heptadecoicate (5) and 2-(1′, 2′, 3′, 4′-tetrahydroxybutyl)-6-(2″, 3″, 4″-trihydroxybutyl)-pyrazine (6), which are isolated for the first time from this species. The structure of 1 was determined to be 1-O-β-D-glucopyranosyl-(2S, 3S, 4R, 10Z)-2-[(2′R)-2′-hydroxylignocenoyl-amino]-10-octadecene-1,3,4-triol on the basis of chemical and spectroscopic evidence.

Keywords:

• Gynura divaricata
• compositae
• cerebrosides
• sphingolipids
• chemical constituents

Acknowledgements

This work was supported by the Scientific Research Fund of the Fujian Provincial Department of Science & Technology (2008Y0086) and the Traditional Chinese Medicine Research Fund of Fujian Provincial Public Health Bureau (wzy0606), China.