A new indole-alkaloid and a new phenolic-glycoside with cytotoxic activity from Strychnos fendleri

Abstract

A new indole alkaloid strychnosinol (1) and a new phenolic-glycoside (2) were isolated from the bark and leaves of Strychnos fendleri Sprague & Sandwith, together with six known compounds reported for the first time in this species. The structures of these compounds were determined on the basis of spectroscopic data; mainly those obtained by using ¹H and ¹³C NMR (1D and 2D) and mass spectrometry. Strychnosinol (1) and the phenolic glycoside (2) together with compounds 3–8 were evaluated for cytotoxicity against a panel of five tumour cell lines; IC₅₀ values between 0.090 and 0.227 μM for the human tumour cell lines were observed for compound 2.

Keywords:

• Strychnos fendleri
• strychnosinol
• phenolic glycoside
• cytotoxicity

Additional information

Funding

This work was supported by FONACIT [grant number PEII-705], [grant number CFI-00293].