Anti-inflammatory flavanol glycosides from Saraca asoca bark

Abstract

Saraca asoca (Roxb.) de Wilde, a common tree of India, is popularly used in the Ayurvedic and modern herbal systems of medicine for genito-urinary problems of women. Considering the reported antimicrobial or anti-inflammatory effect of S. asoca bark against such infections, we studied the anti-inflammatory activity-guided isolation of active compounds from methanol extract. The methanol extract of bark has yielded 10 compounds out of which 3′-deoxyepicatechin-3-O-β-d-glucopyranoside (6) and 3′-deoxycatechin-3-O-α-l-rhamnopyranoside (8) have been found to be in vitro and in vivo active. 3′,5-Dimethoxy epicatechin (3), 3′-deoxyepicatechin-3-O-β-d-glucopyranoside (6), 3′-deoxycatechin-3-O-α-l-rhamnopyranoside (8) and epigallocatechin (9) are being reported for the first time from S. asoca.

Keywords:

• Saraca asoca (Roxb.) de Wild. syn. S. indica Linn
• flavan-3-O-glycosides
• anti TNF-α activity
• anti-inflammatory activity

Acknowledgements

The authors are thankful to DBT, New Delhi for awarding a research grant to carry out this work and Prof. Vasudeva R., College of Forestry, Sirsi (University of Agricultural Sciences, Dharwad), India for providing the plant material. Director CSIR-CIMAP, Lucknow and CSIR-CDRI, Lucknow are thanked for providing the facilities.

Disclosure statement

No potential conflict of interest was reported by the authors.