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Natural Product Research
Formerly Natural Product Letters
Volume 30, 2016 - Issue 24
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Short Communications

Chemical constituents and their bioactivities from the fruits of Vitex negundo var. cannabifolia

Sheng-Tao FangKey Laboratory of Coastal Biology and Biological Resources Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, ChinaCorrespondence[email protected]
,
Na-Na KongKey Laboratory of Coastal Biology and Biological Resources Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, China;College of Resources and Environment, University of the Chinese Academy of Sciences, Beijing, China
,
Bing-Fei YanKey Laboratory of Coastal Biology and Biological Resources Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, China;Chemistry & Chemical Engineering College, Yantai University, Yantai, China
,
Cui-Yun YangKey Laboratory of Coastal Biology and Biological Resources Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, China
,
Jian-Hua WangKey Laboratory of Coastal Biology and Biological Resources Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, China
,
Su-Jing LiuKey Laboratory of Coastal Biology and Biological Resources Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, China
,
Hai-Zhu JinChemistry & Chemical Engineering College, Yantai University, Yantai, China
&
Chuan-Hai XiaKey Laboratory of Coastal Biology and Biological Resources Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, ChinaCorrespondence[email protected]
 show all
Pages 2856-2860 | Received 02 Jul 2015, Accepted 20 Mar 2016, Published online: 19 Apr 2016
 
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Abstract

Phytochemical investigation of the fruits of Vitex negundo var. cannabifolia led to the isolation of 22 compounds (1–22). Their structures were elucidated mainly by spectroscopic analysis and comparison with the literature data. Among them, compounds 1 and 2 were two new artificial lignans. Primary bioassay showed that the polymethoxyflavones 9–12 displayed moderate-to-weak cytotoxicity against human HepG2 and rat C6 cell lines, while the triterpenoids 13–17 exhibited significant brine shrimp lethality with LC50values of 7.5–29.4 μM.

Funding

This work was financially supported by the National Natural Science Foundation of China [grant number 21202198]; the Projects of Natural Key Technology Research and Development Program of the Ministry of Science and Technology of China [grant number 2011BAC02B04].

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