Pleiocarpumlignan A, a new dineolignan from Piper pleiocarpum Chang ex Tseng

Abstract

The investigation of chemical constituents from the whole plants Piper pleiocarpum Chang ex Tseng resulted in the isolation of one new dineolignan, pleiocarpumlignan A (1), along with one known benzoate derivative, trans-2,3-diacetoxy-1-[(benzoy1oxy)methyl]-cyclohexa-4,6-diene (2), and two known neolignans (3–4) as (±)-trans-dehydrodiisoeugenol (3), (7R,8R,3′S)-△^8′-3′,6′-dihydro-3′-methoxy-3,4-methylenedioxy-6′-oxo-8,3′,7,O,4′-lignan (4). Their structures were elucidated through extensive spectroscopic analyses including 1D, 2D NMR, HR-ESI-MS, and by comparison with the literature. All compounds (1–4) were firstly isolated from Piper pleiocarpum Chang ex Tseng. The ¹³C NMR spectra of 2 were completely assigned for the first time. Cytotoxic activities of these isolated compounds against five human cancer cell lines (including A-549, SMMC-7721, HL-60, MCF-7, and SW-480) were evaluated.

Graphical Abstract

Keywords:

• Piper pleiocarpum Chang ex Tseng
• dineolignan
• neolignan
• cytotoxic activities

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work were supported by the Natural Science Foundation of China (NSFC) [grant number 21362035]; The Initial Foundation of Scientific Research for the introduction of talents from Southwest Forestry University for Wen-Hui Xu [grant number 20130916]; and Opening Research Foundation from Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Forestry University.