Antiglycation activity of β-glucogallin from Asparagus racemosus

Abstract

The increased formation and accumulation of advanced glycation end products (AGEs) has been implicated in pathogenesis of various chronic ailments, including diabetes-associated secondary complications, atherosclerosis, aging, inflammatory and neurodegenerative diseases. Therefore, inhibition of AGEs formation is an imperative strategy for alleviating diverse pathologies. Here, we have demonstrated the AGEs inhibitory activity of β-glucogallin, isolated for the first time from the roots of Asparagus racemosus. β-glucogallin significantly mitigated fructose-, glucose- and methylglyoxal-induced glycation of bovine serum albumin (BSA). Also, the presence of β-glucogallin decreased fructosamine and protein carbonyls content, and increased thiol group content in the fructose-BSA system. These activities of β-glucogallin from Asparagus racemosus underscore its likely pharmacological potential for impeding AGEs-related metabolic disorders.

Graphical Abstract

Keywords:

• Antiglycation activity
• AGEs
• asparagus
• β-glucogallin

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the grant from Council of Scientific and Industrial Research (CSIR), New Delhi. This manuscript bears the CDRI Communication number 10340.