Angeliticin B, a new chromone isolated from Angelica polymorpha Maxim

Abstract

A new chromone, angeliticin B (1) together with nine known compounds, psoralene (2), isoimperatorin (3), (S)-(-)-2′-methoxypeucedanin hydrate (4), (S)-(-)-oxypeucedanin (5), xanthotoxin (6), isopimpinellin (7), 1′-O-β-D-glucopyranosyl-(2′S, 3′R)-3′-hydroxymarmesin (8), sec-O-glucosylhamaudol (9) and vanillin (10) were isolated from the methanol extract of Angelica polymorpha Maxim. The structures of these compounds were elucidated through a comprehensive analysis of standard spectral data (MS, IR, and NMR). Compound 1 exhibited antioxidant activity with IC₅₀ = 198.57 μM in DPPH experiment and 31.71 μM in ABTS experiment. Compound 2, 6, 7 exhibited ABTS radical scavenging activity with IC₅₀ ranging from 105.96 μM to 167.67 μM. Compound 3 demonstrated a synergistic induction effect on nigericin-activated NLRP3 inflammasome in THP-1 cell by LDH release method.

Graphical Abstract

Keywords:

• Angelica polymorpha Maxim
• chromone
• coumarin
• antioxidant activity
• NLRP3 inflammasome

Acknowledgments

We would like to thank Prof. Qifeng Chen for providing assistance in the activity experiment section.

Disclosure statement

The authors report there are no competing interests to declare.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.