How do we change our approach to COVID with the changing face of disease?

ABSTRACT

Introduction

The emergence of SARS-CoV-2 triggered a global health emergency, causing > 7 million deaths thus far. Limited early knowledge spurred swift research, treatment, and vaccine developments. Implementation of public health measures such as, lockdowns and social distancing, disrupted economies and strained healthcare. Viral mutations highlighted the need for flexible strategies and strong public health infrastructure, with global collaboration crucial for pandemic control.

Areas covered

(i) Revisiting diagnostic strategies, (ii) adapting to the evolving challenge of the virus, (iii) vaccines against new variants, (iv) vaccine hesitancy in the light of the evolving disease, (v) treatment strategies, (vi) hospital preparedness for changing clinical needs, (vii) global cooperation and data sharing, (viii) economic implications, and (ix) education and awareness- keeping communities informed.

Expert opinion

The COVID-19 crisis forced unprecedented adaptation, emphasizing public health readiness, global unity, and scientific advancement. Key lessons highlight the importance of adaptability and resilience against uncertainties. As the pandemic evolves into a ‘new normal,’ ongoing vigilance, improved understanding, and available vaccines and treatments equip us for future challenges. Priorities now include proactive pandemic strategies, early warnings, supported healthcare, public education, and addressing societal disparities for better health resilience and sustainability.

KEYWORDS:

• SARS-CoV-2
• COVID-19
• COVID
• variants
• mutants
• changing face of COVID

Article highlights

• SARS-CoV-2 caused global catastrophe with over 7 million deaths and strained healthcare systems.

• Initial lack of understanding led to rapid research for transmission, pathogenicity, and treatments.

• Pandemic enforced lockdowns, travel restrictions, causing economic decline and unemployment.

• Emergence of viral variants highlighted need for adaptable public health strategies and resources.

• Global scientific cooperation accelerated vaccine, diagnostic, and therapy development, mitigating pandemic impact.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This paper was not funded.