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Original Articles

Mismatch negativity (MMN) as an index of central auditory system plasticity

Pages S16-S20 | Received 10 Jun 2008, Published online: 07 Jul 2009
 

Abstract

The mismatch negativity (MMN) is an electric brain response which is automatically elicited by any discriminable change in a repetitive sound or sound pattern. When this change is made smaller in magnitude, the MMN is attenuated in amplitude, eventually vanishing at around the discrimination threshold. Therefore the MMN provides a unique objective index for a subject or patient's discrimination accuracy. Furthermore, with the MMN, these discrimination thresholds can be separately determined for all the different auditory attributes. Moreover, the individual's ability to discriminate complex sound stimuli and patterns such as different phonemes can also be measured by using the MMN.

Abbreviations
ISI=

Interstimulus interval

MEG=

Magnetoencephalography

MMN=

Mismatch negativity

Abbreviations
ISI=

Interstimulus interval

MEG=

Magnetoencephalography

MMN=

Mismatch negativity

Sumario

La negatividad dispar (MMN) es una respuesta eléctrica cerebral que se evoca automáticamente por la discriminación de un cambio en un sonido repetitivo o patrón sonoro. Cuando este cambio es de magnitud menor, la MMN se atenúa en amplitud, eventualmente desapareciendo alrededor del umbral de discriminación. Por consiguiente la MMN proporciona un índice objetivo único de la exactitud en la discriminación de un sujeto o paciente. Además con la MMN, estos umbrales de discriminación pueden ser determinados separadamente para todos los diferentes atributos auditivos. Incluso, también se puede utilizar la MMN para medir la habilidad del individuo para discriminar estímulos de sonidos complejos y patrones tales como fonemas diferentes.

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