Children with amblyaudia show less flexibility in auditory cortical entrainment to periodic non-speech sounds

Abstract

Objective

We investigated auditory temporal processing in children with amblyaudia (AMB), a subtype of auditory processing disorder (APD), via cortical neural entrainment.

Design and study samples

Evoked responses were recorded to click-trains at slow vs. fast (8.5 vs. 14.9/s) rates in n = 14 children with AMB and n = 11 age-matched controls. Source and time–frequency analyses (TFA) decomposed EEGs into oscillations (reflecting neural entrainment) stemming from bilateral auditory cortex.

Results

Phase-locking strength in AMB depended critically on the speed of auditory stimuli. In contrast to age-matched peers, AMB responses were largely insensitive to rate manipulations. This rate resistance occurred regardless of the ear of presentation and in both cortical hemispheres.

Conclusions

Children with AMB show less rate-related changes in auditory cortical entrainment. In addition to reduced capacity to integrate information between the ears, we identify more rigid tagging of external auditory stimuli. Our neurophysiological findings may account for domain-general temporal processing deficits commonly observed in AMB and related APDs behaviourally. More broadly, our findings may inform communication strategies and future rehabilitation programmes; increasing the rate of stimuli above a normal (slow) speech rate is likely to make stimulus processing more challenging for individuals with AMB/APD.

Keywords:

• Auditory processing disorders (APD)
• event-related brain potentials (ERPs)
• gamma/beta band response
• hemispheric asymmetries
• phase-locking
• time–frequency analysis

Acknowledgments

We thank Drs. Karen Bell and Caitlin Price for comments on earlier versions of this manuscript. Requests for data and materials should be directed to G.M.B. [[email protected]].

Author contributions

D.W.M. designed the experiment and collected the data; S.M. and M.A.R. analysed the data; all authors wrote the article.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the National Institute on Deafness and Other Communication Disorders of the NIH under award number R01DC016267 (G.M.B.), the U.S. Department of Education under award number H325K100325 (D.M.), and the Lions Hearing Research Foundation (D.M.).