The Use of Propofol for Continuous Deep Sedation at the End of Life: A Definitive Guide

Abstract

The anesthetic propofol is used in a number of medical applications including surgery, procedural sedation, refractory status epilepticus, alcohol withdrawal, and critical care sedation. The manner in which it is dosed and administered in each environment varies, tailored to the specific task at hand. Because the use of propofol in end-of-life care is uncommon, providers may lack practical experience, and resources that are specific to this specialized application are not comprehensive and largely based on dosing and administration as it is done on the intensive care unit. The purpose of this review is to provide an evidence and experienced based reference for the specific use of propofol for end of life sedation.

Keywords:

• Palliative sedation
• continuous deep sedation
• propofol
• withdrawal of care
• refractory symptoms