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Review

The Risk of QTc Prolongation with Antiemetics in the Palliative Care Setting: A Narrative Review

ORCID Icon, , , &
Pages 125-135 | Received 23 Nov 2020, Accepted 03 Mar 2021, Published online: 11 May 2021
 

Abstract

Nausea and vomiting are common within the palliative care population. Antiemetic agents may help control symptoms, but may also place patients at risk for QTc prolongation. This article reviews pharmacotherapy agents including anticholinergics, antihistamines, antidopaminergics, 5-HT3 receptor antagonists, dronabinol, and medical marijuana and their associated risk of QTc prolongation. A clinical treatment pathway is provided to help guide clinicians in choosing the most appropriate antiemetic based upon patient specific factors for QTc prolongation.

Declaration of interest

None reported.

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