Synergistic interactions between temporal coupling of complex light and magnetic pulses upon melanoma cell proliferation and planarian regeneration

ABSTRACT

Synergisms between a physiologically patterned magnetic field that is known to enhance planarian growth and suppress proliferation of malignant cells in culture and three light emitting diode (LED) generated visible wavelengths (blue, green, red) upon planarian regeneration and melanoma cell numbers were discerned. Five days of hourly exposures to either a physiologically patterned (2.5–5.0 μT) magnetic field, one of three wavelengths (3 kLux) or both treatments simultaneously indicated that red light (680 nm), blue light (470 nm) or the magnetic field significantly facilitated regeneration of planarian compared to sham field exposed planarian. Presentation of both light and magnetic field conditions enhanced the effect. Whereas the blue and red light diminished the growth of malignant (melanoma) cells, the effect was not as large as that produced by the magnetic field. Only the paired presentation of the blue light and magnetic field enhanced the suppression. On the other hand, the changes following green light (540 nm) exposure did not differ from the control condition and green light presented with the magnetic field eliminated its effects for both the planarian and melanoma cells. These results indicate specific colors affect positive adaptation that is similar to weak, physiologically patterned frequency modulated (8–24 Hz) magnetic fields and that the two forms of energy can synergistically summate or cancel.

KEYWORDS:

• Planarian
• LEDs
• melanoma cells
• weak magnetic fields
• light-magnetic field synergism
• red light
• green light
• blue light

5. Conclusion

The results of the present experiments demonstrated that both appropriately patterned magnetic fields and blue or red LED-generated wavelengths can comparably facilitate normal regeneration of planarian. The light was less effective than the magnetic field for suppression of malignant cell’s abnormal proliferation. When the field and red or blue lights are pulsed together coherently the beneficial effects are enhanced. On the other hand the effects of exposure to green light did not differ from reference groups for cells or planarian. The simultaneous presentation of the magnetic field and the green light totally eliminated the facilitative effect of the magnetic field on planarian regeneration and the inhibitory effect for melanoma cell proliferation.

Declaration of Interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.