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Behavioral Sleep Medicine Volume 18, 2020 - Issue 1
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Association of Anxiety and Depression in Obstructive Sleep Apnea Patients: A Systematic Review and Meta-Analysis

Sergio GarbarinoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal/Child Sciences (DINOGMI), University of Genoa, Genoa, Italy;Department of Health Sciences, University of Genoa, Genoa, Italy
,
Wayne A. BardwellDepartment of Psychiatry, University of California San Diego, San Diego, California
,
Ottavia GuglielmiDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal/Child Sciences (DINOGMI), University of Genoa, Genoa, ItalyCorrespondence[email protected]
,
Carlo ChiorriDepartment of Educational Sciences, University of Genoa, Genoa, Italy
,
Enrica BonanniCenter of Sleep Medicine, Neurology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy
&
Nicola MagnavitaInstitute of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy
Pages 35-57 | Published online: 19 Nov 2018
 
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ABSTRACT

Background: Obstructive sleep apnea (OSA) has been associated with mental disorders, but the strength of this association is unknown. The aim of our study was to investigate the association among OSA, depression, and anxiety in adults and to quantitatively summarize the results. Methods: A literature search in Medline, PubMed, PsycInfo, Scopus, and Web of Science was conducted. Seventy-three articles were selected for study. Results: The pooled prevalence of depressive and anxious symptoms in OSA patients was 35% (95% CI, 28–41%) and 32% (95% CI, 22–42%), respectively. Conclusions: The association between OSA, anxiety, and depression indicates the value of an early diagnosis and personalized treatment of OSA to improve mental disorders conditioning compliance to therapy. These conditions share a probably bidirectional relationship.

Disclosure statement

No potential conflict of interest was reported by the authors.

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