Synthesis, characterization, and crystal structure analysis of 2-(2-hydroxy-3-methoxyphenyl)-1-(4-chlorophenyl)-4,5-diphenyl-1h-imidazole

ABSTRACT

The substituted imidazole C₂₈H₂₁ClN₂O₂, was prepared via multicomponent reactions and the product crystallized using dimethylformamide. The structure of the compound was established by elemental analysis, Fourier transform infrared spectroscopy, thermogravimetric analysis, UV-visible, proton nuclear magnetic resonance spectroscopy, and single-crystal X-ray diffraction. The molecule is crystallized in the tetragonal crystal system with the space group P4₃2₁2 and with unit cell parameters a = 12.246(4) Å, b = 12.246(4) Å, c = 31.781(2) Å, and Z = 8. The molecular and crystal structures of the title molecule are stabilized by the intramolecular interactions, O-H···N and C-H···N, and intermolecular interaction, C-H···O.

KEYWORDS:

• Crystallization
• crystal structure
• imidazole
• intermolecular interactions
• FTIR spectrum
• Hirshfeld surface
• multicomponent reaction
• thermogram

Acknowledgments

Authors thank the Institution of Excellence, Vigyana Bhavan, University of Mysore, Mysore, India, for providing single crystal X-ray diffraction facility to collect the data. The author V.S. gratefully acknowledge the UGC and DST-PURSE for the financial assistance and Mangalore University, USIC and MICROTONE center for their instrumental facilities. NMR research center Bangalore for the NMR spectrum.