The Association Between Serological Markers of Celiac Disease and Idiopathic Recurrent Pregnancy Loss

ABSTRACT

Introduction: Antiphospholipid syndrome, uterine anomalies, and chromosomal aberrations are identifiable causes of recurrent pregnancy loss (RPL). Herein, our aim is to investigate the relationship between celiac disease (CD) specific antitransglutaminase antibodies (ATA) and unexplained RPL. Materials and Methods: This was a cross sectional case-control study conducted on 86 women (45 RPL and 41 controls) in a tertiary level maternity hospital. Elisa kit was used to determine ATA IgA and IgG levels. Results: One (2.2%) patient with ATA IgG positivity was present in the RPL group. There were three (7.3%) cases with positive for ATA IgA in the control group, and one (2.2%) case in the study group. No statistically significant differences were observed between the groups in terms of ATA IgG and IgA. Conclusion: There is no association between CD markers and unexplained RPL. For the present, we do not recommend screening for ATA IgA and ATA IgG in patients with a history of RPL.

KEYWORDS:

• Celiac disease
• habitual abortion
• recurrent miscarriage
• antitransglutaminase antibody

Declaration of Interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.