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Fetal and Pediatric Pathology Volume 39, 2020 - Issue 6
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Association of IL-6 -176G > C Polymorphism with Susceptibility to Preeclampsia: A Systematic Review and Meta-Analysis

Mehrnaz VeisianDepartment of Gynecology and Obstetrics, Isfahan University of Medical Sciences, Isfahan, Iran;
,
Atiyeh JavaheriDepartment of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Correspondence[email protected]
,
Nooshin AmjadiDepartment of Gynecology and Obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
,
Razieh Sadat TabatabaeiDepartment of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;
,
Leila ZanbaghDepartment of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; ;Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran;
,
Amaneh HadadanDepartment of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; ;Department of Gynecology and Obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
,
Hajar AbbasiDepartment of Gynecology and Obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
,
Erfaneh SalimiDepartment of Gynecology and Obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
,
Seyed Alireza DastgheibDepartment of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
&
Hossein NeamatzadehDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; ;Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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Pages 491-502 | Received 27 Aug 2019, Accepted 17 Sep 2019, Published online: 18 Nov 2019
 
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Abstract

Background: Many studies have described the influence of -176G > C polymorphism of the IL-6 gene on susceptibility to preeclampsia. However, the results have remained inconclusive and controversial. Therefore, we performed a meta-analysis to more precisely determine the association between the IL-6 -176G > C polymorphism and preeclampsia risk. Methods: Electronic databases including PubMed, Embase, Web of Science, and CNKI were searched up to August 15, 2019. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were used to calculate the association. Results: A total of 12 studies with 1,821 preeclampsia cases and 3,339 controls were selected. Overall, no significant association was found between IL-6 -176G > C polymorphism and preeclampsia risk. In the stratified analyses by ethnicity, there was a significant association in Asians, but not in Caucasians and mixed populations. Conclusions: The results of meta-analysis indicated that IL-6 -176G > C polymorphism was not significantly associated with risk of preeclampsia in overall population.

Disclosure statement

No potential conflict of interest was reported by the authors.

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