Investigation of In Vitro Release of Cisplatin from Electrostatically Crosslinked Chitosan-Alginate Nanoparticles

Abstract

The major aim of this study was to design chitosan/alginate nanoparticles as swelling controlled drug release system for anticancer drugs. The prepared nanoparticles were characterized by FTIR and transmission electron microscopy analysis and their biocompatibility and in vitro cytotoxicity were evaluated. The nanoparticles were loaded with widely used anticancer drug, cisplatin, and controlled release of drug was investigated to observe the effects of various parameters such as percent loading of the drug, pH, temperature, and nature of release media on the release profiles. The release of cisplatin was also studied in various simulated biological fluids.

Keywords:

• chitosan/alginate
• nanoparticles
• cisplatin
• drug delivery system