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Inorganic and Nano-Metal Chemistry Volume 47, 2017 - Issue 1
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Articles

Synthesis, crystal structures, and biological activity of zinc(II) complexes derived from 2-amino-1,3,4-thiadiazole derivatives

Hui-Long ZhuSchool of Pharmaceutical Sciences, Huaihai Institute of Technology, Lianyungang, P. R. China
,
Yu-Wei LiuSchool of Pharmaceutical Sciences, Huaihai Institute of Technology, Lianyungang, P. R. China;College of Pharmaceutical Sciences, Soochow University, Suzhou, P. R. China
,
Zong-Ming TangSchool of Pharmaceutical Sciences, Huaihai Institute of Technology, Lianyungang, P. R. China
,
Fu-Jun YinJiangsu Institute of Marine Resources, Lianyungang, P. R. China
,
Wei-Wei LiuSchool of Pharmaceutical Sciences, Huaihai Institute of Technology, Lianyungang, P. R. China
,
Zhi-Ling CaoSchool of Pharmaceutical Sciences, Huaihai Institute of Technology, Lianyungang, P. R. China
,
Juan BaoSchool of Pharmaceutical Sciences, Huaihai Institute of Technology, Lianyungang, P. R. China
,
Meng LiSchool of Pharmaceutical Sciences, Huaihai Institute of Technology, Lianyungang, P. R. China
,
Ling-Yan QinSchool of Pharmaceutical Sciences, Huaihai Institute of Technology, Lianyungang, P. R. China
&
Da-Hua ShiSchool of Pharmaceutical Sciences, Huaihai Institute of Technology, Lianyungang, P. R. China;Jiangsu Institute of Marine Resources, Lianyungang, P. R. China;Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Lianyungang, P. R. ChinaCorrespondence[email protected]
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Pages 78-81 | Received 25 Apr 2015, Accepted 30 Jan 2016, Published online: 07 Jun 2016
 
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ABSTRACT

Two new similar zinc(II) complexes, [ZnCl2L12] and [ZnCl2L22], derived from the 2-amino-1,3,4-thiadiazole derivatives, were prepared and structurally characterized by X-ray diffraction. The Zn atom in each complex has a tetrahedral coordination and is coordinated by two N atoms of the ligands and two Cl atoms. The urease inhibitory activities of the complexes and the ligands were evaluated.

Funding

The financial support of the Science and Technology Project of Lianyungang (CG1202), Collegiate Natural Science Fund of Jiangsu Province (12KJB350001, 13KJB150006) and Natural Science Foundation of Jiangsu Province (BK20141246), and the Priority Academic Program Development of Jiangsu Higher Education Institutions are gratefully acknowledged.

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