Diphoterine® Chemical Splash Decontamination Solution: Skin Sensitization Study in the Guinea Pig

Abstract

Diphoterine® is an active eye/skin chemical splash decontamination solution. It was evaluated for sensitization potential in the guinea pig with primary induction (day 1, intradermal injection), sensitization (day 9, topical application), and challenge (day 22, topical application). Allergenicity degree at 24 and 48 hours was based on the percentage of animals showing a reaction. Under these conditions, no irritation was noted at 24 and 48 hours in negative controls and in animals treated with Diphoterine during the challenge phase. Diphoterine showed no allergenicity at 24 and 48 hours. In this study, Diphoterine lacked sensitizing capacity in the guinea pig.

Keywords :

• Diphoterine®
• Skin, chemical splash
• Skin, decontamination
• Skin, sensitization

Notes

Presented at the Society of Toxicology Annual Meeting, March 2004, Baltimore, MD, USA and the International Congress of Toxicology, July 2004, Tampere, Finland.