The efficacy of HDDPiW-jSB solution on docetaxel-induced alopecia of rats

Abstract

Objective

Chemotherapy induced alopecia (CIA) is one of the most common side effects in cancer patients, however; it doesn’t have an effective pharmacological treatment yet. In this study we aimed to research the protective effect of newly developed HDDPiW-jSB solution on docetaxel (DTX) -induced rat alopecia model.

Material and Methods

Docetaxel (10 mg/kg/week) was administered to the 6–8 months old rats for three weeks. HDDPiW-jSB solution was applied once or twice a week for 4 weeks beginning prior to one week before DTX. Rat hair follicles were evaluated with hematoxylin-eosin and immune-histochemical staining.

Results

In the first stage of this study, alopecia was successfully developed by DTX (10 mg/kg/three times) application. In the second stage of the study, application of HDDPiW-jSB solution, did not change the study parameters significantly on control group. The solution improved the anagen hair follicle count and Bcl-2 levels in the skin samples of DTX-induced alopecic rat groups, especially when applied twice weekly. Additionally, level of Caspase 3 was decreased. HDDPiW-jSB solution was safe when applied on the skin.

Conclusion

Topical HDDPiW-jSB solution could be effective and safe for the protection of DTX-induced alopecia in rat models.

Keywords:

• Chemotherapy induced alopecia
• docetaxel
• hair loss
• oncology
• animal research

Author contributions

All authors have made substantial contributions to conception, design, acquisition of data; or analysis and interpretation of data; or have been involved in drafting the manuscript or revising it critically for important intellectual content.

Ethical approval

Aydin Adnan Menderes University for Animal Experiments (HADYEK 64583101/2020/075).

Disclosure statement

Author declares no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Data availability statement

The data sets and data analysed in the study are available from the corresponding author on reasonable request.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.