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Toxin Reviews Volume 37, 2018 - Issue 2
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Research Article

Gastroprotective effects of amifostine in rats treated by T-2 toxin

Vesna JacevicNational Poison Control Centre, Military Medical Academy, Belgrade, Serbia, ;Medical Faculty of the Military Medical Academy, University of Defence, Belgrade, Serbia, ;Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic,
,
Kamil KucaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic, ;Biomedical Research Centre, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic,
,
Zoran MilovanovicBelgrade Police Administration, Belgrade, Serbia,
,
Aleksandra Bocarov-StancicInstitute for Science Application in Agriculture, Belgrade, Serbia,
,
Ilija RancicMedical Faculty of the Military Medical Academy, University of Defence, Belgrade, Serbia,
,
Dubravko BokonjicMedical Faculty of the Military Medical Academy, University of Defence, Belgrade, Serbia,
,
Viktorija Dragojevic-SimicMedical Faculty of the Military Medical Academy, University of Defence, Belgrade, Serbia, ;Center for Clinical Pharmacology, Military Medical Academy, Belgrade, Serbia, and
&
Zoran SegrtMedical Faculty of the Military Medical Academy, University of Defence, Belgrade, Serbia, ;Department for Treatment, Military Medical Academy, Belgrade, SerbiaCorrespondence[email protected]
 show all
Pages 123-127 | Received 01 Nov 2016, Accepted 08 May 2017, Published online: 25 May 2017
 
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Abstract

Cytoprotector amifostine (AMI) was given in a dose of 50, 100 or 150 mg/kg ip in rats treated with several highly toxic doses of T-2 toxin. The best survival rate (24 h and 7 days after treatment) was obtained with AMI50 (50 mg/kg ip). After T-2 intoxication, a peak in the mean number of gastric lesions (petechiae and ulcerations) was reached on the third day (26.40 ± 6.24). Administration of AMI50 reduced, almost completely, the total number of gastric lesions in rats acutely poisoned by 0.5 LD50 T-2 (1.5 mg/kg sc), starting with day 1 after intoxication (5.60 ± 3.42).

Acknowledgements

This work received partial financial support from the Ministry of Education, Science and Technological Development of the Republic of Serbia, and from the Ministry of Defense of the Republic of Serbia. This work was also supported by long-term development plan UHK and UHHK of the Czech Republic.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

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