Preventive effects of hesperidin on diabetic nephropathy induced by streptozotocin via modulating TGF-β1 and oxidative DNA damage

Abstract

Hesperidin (HSP) is a natural bioflavonoid with active pharmacological properties. This study was conducted to investigate the hypoglycemic and antioxidant effects of HSP on streptozotocin-induced diabetic nephropathy in rats. Serum urea, creatinine and malondialdehyde levels increased in the diabetic group, while antioxidant enzyme activities decreased compared to the control group. Moreover, transforming growth factor-beta 1 level, 8-hydroxy-2′-deoxyguanosine expression and histopathological changes in renal tissue were increased in the diabetic group. On the other hand, HSP therapy significantly regulated these values in diabetic rats. Our results indicated that HSP might be helpful to protect diabetic nephropathy.

Keywords:

• Diabetic nephropathy
• hesperidin
• TGF-β1
• 8-OHdG
• streptozotocin

Disclosure statement

The authors declare that there is no conflict of interest.

Additional information

Funding

Ataturk UniversityBAP 2015/53This study was supported by Ataturk University, Foundation of Scientific Researches Projects (Project number: BAP 2015/53).