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Toxin Reviews Volume 37, 2018 - Issue 4
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Research Article

Nitrosative DNA damage after sub-chronic exposure to silver nanoparticle induces stress nephrotoxicity in rat kidney

Akram RanjbarDepartment of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran; View further author information
,
Farzin FirozianDepartment of Pharmaceutical, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran; View further author information
,
Sara Soleimani AslDepartment of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; View further author information
,
Hassan GhasemiAbadan School of Medical Sciences, Abadan, Iran; View further author information
,
Masumeh Taheri AzandarianiDepartment of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; View further author information
,
Amir LarkiDepartment of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran; View further author information
,
Nejat KheiripourDepartment of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Correspondence[email protected]
View further author information
,
Asieh HosseiniRazi Drug Research Center, Iran University of Medical Sciences, Tehran, IranView further author information
&
Arman NaserabadiDepartment of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran; Correspondence[email protected]
View further author information
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Pages 327-333 | Received 09 Jul 2017, Accepted 27 Sep 2017, Published online: 03 Nov 2017
 
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Abstract

The current study was designed to find the effects of silver nanoparticles (AgNPs) against rat serum and kidney oxidative stress biomarkers. Urea, creatinine (Cr), total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol groups (TTG), DNA damage, and nitric oxide (NO) were measured by spectrophotometric and immunoassay methods. Histopathological evaluation was performed using H&E staining. AgNP (250 ppm) caused a significant increase in kidney and serum oxidative stress biomarkers, serum concentrations of urea and Cr when compared to control group (p < .05). Our findings suggest that antioxidant properties of AgNP are in dose-dependent manner.

Disclosure statement

The authors have declared no conflicts of interest.

Additional information

Funding

The authors acknowledge Hamadan University of Medical Sciences (Hamadan, Iran) for financial support of this study (Project number 940201446).

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