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Toxin Reviews Volume 40, 2021 - Issue 4
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Review

Genetic susceptibility to nicotine and/or alcohol addiction: a systematic review

Isabel Legaza University of Murcia - Espinardo Campus, Murcia, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1140-4313
ORCID Icon,
M. D. Pérez-Cárcelesb Department of Legal and Forensic Medicine, Biomedical Research Institute (IMIB), Regional Campus of International Excellence “Campus Mare Nostrum”, Faculty of Medicine, University of Murcia, Murcia, SpainORCID Iconhttps://orcid.org/0000-0003-1879-2969
ORCID Icon,
Irene de la Callea University of Murcia - Espinardo Campus, Murcia, Spain
,
Fuensanta Arjonaa University of Murcia - Espinardo Campus, Murcia, Spain
,
Miriam Rocaa University of Murcia - Espinardo Campus, Murcia, Spain
,
Pablo Cejudoa University of Murcia - Espinardo Campus, Murcia, Spain
,
Aurelio Lunaa University of Murcia - Espinardo Campus, Murcia, SpainORCID Iconhttps://orcid.org/0000-0001-7760-7415
ORCID Icon &
Eduardo Osunaa University of Murcia - Espinardo Campus, Murcia, Spain
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Pages 371-382 | Received 01 Mar 2019, Accepted 11 May 2019, Published online: 23 May 2019
 
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Abstract

Recent studies have confirmed the wide consumption of tobacco and alcohol in our society and the strong addiction generated by these substances, which is responsible for high public health expenditure. Understanding the biological mechanisms of nicotine and/or alcohol dependence should have huge public health repercussions in the future. The aim of this review was to analyze the main human genes and polymorphisms related to nicotine and/or alcohol addiction, to help understand the biological mechanisms involved and which may be useful for developing new treatments in the future.

Disclosure statement

No potential conflict of interest was reported by the authors.

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