The effects of co-administration of marijuana and methylphenidate on spatial learning and memory in male rats

Abstract

The aim of the present study was to evaluate the acute effects of combined use of marijuana and Methylphenidate (MPD) on cognition performance of male rats. Rats received marijuana, MPD and co-administration of effective & ineffective doses of both. Spatial learning and memory were evaluated by Morris Water Maze (MWM) apparatus. MPD revealed significant beneficial effects on learning process while marijuana caused a significant impairment in learning. MPD administration did not attenuate the marijuana induced memory impairment. Co-administration of MPD and marijuana was associated with significant impairment in learning, without any significant effect on memory.

Keywords:

• MPD
• marijuana
• learning and memory
• Morris Water Maze
• male rat

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by a grant from Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.