Low toxicity in hematological and biomedical parameters caused by bupernorphine in lactating female rats and their newborns

Abstract

This study was designed to evaluate the toxic effects of buprenorphine (BUP) on hematological and serum biochemical parameters of female rats and their pups. Lactating rats received BUP 0.1 and 0.3 mg/kg subcutaneously for 21 days. Then, the female rats and their pups were anesthetized. Their blood samples were collected to assess hematological parameters and serum biochemical parameters. BUP decreased the hematocrit value and the percentage of lymphocytes (p < .05) but increased the percentage of neutrophils (p < .01) in pups exposed to BUP (0.3 mg/kg) versus the controls. We showed that some hematological parameters are altered in pups exposed to BUP solely via breastmilk.

Keywords:

• Biochemical parameters
• buprenorphine
• hematological parameters
• immunological lactation
• newborn
• parameters
• rat

Acknowledgements

The authors would like to thank Research Affairs of Neyshabur University of Medical Sciences for financially supporting this work.

Disclosure statement

No potential conflict of interest was reported by the authors.