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Toxin Reviews Volume 40, 2021 - Issue 4
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Research Article

Chlorella vulgaris supplementation attenuates the progression of liver fibrosis through targeting TGF-β-signaling pathway in the CCl4-induced liver fibrosis in rats

Roohollah Mohsenia Student research committee, Hamadan University of Medical Sciences, Hamadan, Iran;b Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranView further author information
,
Zahra Arab Sadeghabadic Department of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, IranView further author information
,
Jamshid Karimic Department of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, IranCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8253-7124View further author information
ORCID Icon,
Hamid Gholamic Department of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, IranView further author information
,
Hadi Ghasemic Department of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, IranView further author information
,
Hamid Reza Ghadimipourd Department of Pathology, Hamadan University of Medical Sciences, Hamadan, IranView further author information
&
Nejat Kheiripoure Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IranView further author information
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Pages 1347-1355 | Received 17 Jan 2019, Accepted 30 Nov 2019, Published online: 13 Dec 2019
 
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Abstract

The purpose of this study is to investigate the molecular mechanism underlying hepatoprotective effect of Chlorella vulgaris extract (CVE). The administration of both doses of CVE attenuated liver damage and decreased serum markers and oxidative stress parameters dramatically. Also, CVE treatment downregulated hepatic gene expression of collagen type1 (Col1a1), fibronectin (Fn1), transforming growth factor-beta 1 (Tgfb1), transforming growth factor-beta receptor 2 (Tgfbr2) and SMAD family member 3 (Smad3) significantly. Hepatic level of TGF-β1 protein was decreased by CVE treatment significantly. CVE supplementation restraints liver fibrosis progression through amelioration of oxidative stress status and targeting TGF-β signaling pathway.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by Hamadan University of Medical Sciences (No: 9511126747).

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