Ameliorative role of metformin on lipopolysaccharide-mediated liver malfunction through suppression of inflammation and oxidative stress in rats

Abstract

Liver is susceptible to oxidative stress and inflammation. The effect of metformin on lipopolysaccharide (LPS)-mediated liver malfunction was investigated. Rats were grouped into (1) control, (2) LPS, (3–5) LPS as well as 50, 100, and 150 mg/kg of metformin for 5 weeks. LPS increased liver enzymes, IL-6, and malondialdehyde (MDA) (p < 0.05 and p < 0.001) whereas metformin reduced them (p < 0.05 to p < 0.001). LPS decreased total protein, albumin, total thiol, SOD and CAT (p < 0.05 and p < 0.001), and metformin attenuated the effect of LPS (p < 0.05 to p < 0.001). The protective effect of metformin is probably mediated via suppression of inflammation and improvement of oxidative stress status.

Keywords:

• Lipopolysaccharide
• liver
• inflammation
• oxidative stress

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The present work was financially supported by the Vice Chancellor for Research and Technology of Jiroft University of Medical Sciences (Project No. 961613).