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The World Journal of Biological Psychiatry Volume 7, 2006 - Issue 3
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ORIGINAL INVESTIGATION

Association study of the glycogen synthase kinase-3β gene polymorphism with prophylactic lithium response in bipolar patients

Aleksandra Szczepankiewicz Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, PolandCorrespondence[email protected]
,
Janusz K. Rybakowski Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
,
Aleksandra Suwalska Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
,
Maria Skibinska Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
,
Anna Leszczynska-Rodziewicz Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
,
Monika Dmitrzak-Weglarz Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
,
Piotr M. Czerski Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
&
Joanna Hauser Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
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Pages 158-161 | Received 20 Jul 2005, Published online: 12 Jul 2009
 
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Abstract

A relationship between response to lithium prophylaxis and T-50C polymorphism of glycogen synthase kinase-3β (GSK-3β) gene was investigated in 89 bipolar patients (41 male and 48 female) who have been taking lithium for at least 5 years. The patients were delineated as excellent responders, partial responders and non-responders to lithium. The results obtained suggest that this polymorphism may not be related to the degree of prophylactic lithium response.

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