Calcium silicate-based drug delivery systems

ABSTRACT

Introduction: Compared with other inorganic materials such as silica, metal oxides, noble metals and carbon, calcium silicate-based materials, especially nanostructured calcium silicate materials, have high biocompatibility, bioactivity and biodegradability, high specific surface area, nanoporous/hollow structure, high drug-loading capacity, pH-responsive drug release behavior and desirable drug release properties, and thus they are promising for the application in drug delivery. Calcium silicate-based drug delivery systems have a long drug-release time, which can significantly prolong the therapeutic effect of drugs. Another advantage of calcium silicate-based drug delivery systems is their pH-responsive drug release property, which can act as an ideal platform for targeted drug delivery.

Areas covered: In recent years, studies have been carried out on calcium silicate-based drug delivery systems, and important results and insights have been documented. This article is not intended to offer a comprehensive review on the research on calcium silicate-based drug delivery systems, but presents some examples reported in the literature, and includes new insights obtained by tracking the interactions between drug molecules and calcium silicate carriers on the molecular level using the synchrotron-based X-ray spectroscopy.

Expert opinion: Finally, our opinions on calcium silicate-based drug delivery systems are provided, and several research directions for the future studies are proposed.

KEYWORDS:

• Calcium silicate
• nanostructured materials
• drug delivery
• synchrotron spectroscopy

Article highlights

• A brief review on calcium silicate-based drug delivery systems

• Nanostructured calcium silicate materials have high biocompatibility, bioactivity and biodegradability, high specific surface area, nanoporous/hollow structure, high drug loading capacity, pH-responsive drug release behavior and desirable drug release properties, and thus they are promising for the application in drug delivery

• Calcium silicate-based drug delivery systems have long drug release times and pH-responsive drug release property, which can significantly prolong the therapeutic effect of drugs and act as an ideal platform for targeted drug delivery

• Some new insights obtained by tracking the interactions between drug molecules and calcium silicate carrier materials on the molecular level using the synchrotron-based X-ray spectroscopy are discussed

• Our opinions on calcium silicate-based drug delivery systems are provided

• Several research directions on calcium silicate-based drug delivery systems for the future studies are proposed

This box summarizes key points contained in the article.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

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Additional information

Funding

This paper was not funded.