Analysis of clinical outcomes and prognosis of patients with early bronchogenic lung cancer after treatment of rigid bronchoscopy combining fiberoptic bronchoscopy: a single-center retrospective study

ABSTRACT

Objectives

To investigate the clinical value of rigid bronchoscopy combined with fiberoptic bronchoscopy in patients with early bronchogenic lung cancer who underwent sleeve lobectomy.

Methods

A retrospective study was performed on 76 patients with early bronchogenic lung cancer admitted to our center from March 2016 to March 2017. Patients in the control group received conventional sleeve lobectomy (n = 38), while patients in the observation group underwent sleeve lobectomy by using rigid bronchoscopy combining fiberoptic bronchoscopy (n = 38). We compared perioperative period indicators and the recovery of pulmonary function indexes one month after the operation were compared in two groups. The prognosis of the patients were also analyzed.

Results

Compared with the control group, the intraoperative blood loss, operation duration and airway reconstruction duration in the observation group were significantly reduced. The total incidence of perioperative complications was markedly lower in the observation group than in the control group. The percentage of DLCO% was significantly improved in the observation group. The relapse-free survival (RFS) in the observation group was remarkably longer than in the control group.

Conclusion

Rigid bronchoscopy combined with fiberoptic bronchoscopy is beneficial to improve the clinical outcome and prognosis of patients with early bronchogenic lung cancer more effectively.

KEYWORDS:

• Rigid bronchoscopy
• fiberoptic bronchoscopy
• sleeve lobectomy
• early bronchogenic lung cancer
• clinical outcome
• prognosis

Article highlights

• Rigid bronchoscopy combined with fiberoptic bronchoscopy can make up for the shortcomings of the two in use.

• The combination of the two bronchoscopies can reduce the amount of intraoperative blood loss, and shorten operation time as well as airway reconstruction time.

• Bronchial sleeve resection with rigid bronchoscopy combined with fiberoptic bronchoscopy is more beneficial to patients’ short-term improvement in lung function and long-term prognosis.

• Routine bronchial sleeve resection is an independent risk factor for recurrence in patients with early bronchogenic lung cancer.

• It is necessary to further evaluate the clinical effect of the combination of the two bronchoscopies.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or material discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or mending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Ethics approval and consent to participate

The study was approved by the Ethical Committee of Yiyang Central Hospital (No.2020–024).

Data availability statement

The data that support the findings of this study are available from the corresponding author.

Author contributions

Zhengbing He and Juhua Hou participated in the design and interpretation of the data and drafting/revising the manuscript. Wenguang Liu conceived of the study, and participated in its design and interpretation and helped to draft the manuscript. Yong Li performed the statistical analysis and revised the manuscript critically. Yu Li and Wei Zeng participated in its design and interpretation.

All the authors read and approved the final manuscript.

Additional information

Funding

This paper was funded by the Appropriate Technology Promotion Project of Hunan Provincial Health Commission [grant numbers 202218011583].