Impact of ischemia time during partial nephrectomy on short- and long-term renal function

Abstract

Objective

Partial nephrectomy is the gold standard treatment in small renal tumours. During partial nephrectomy, the renal artery is clamped which creates transient ischemia. This can damage nephrons and may affect kidney function immediately postoperatively and on long-term.

In the present study, we investigated the effect of ischemia time during partial nephrectomy with regards to affection of renal function immediately post-operatively and 1-year post-surgery.

Materials and method

A retrospective cohort study including 124 patients who underwent partial nephrectomy at a single regional hospital in the period from 2018 to 2020 was conducted.

Results

We divided patients into subgroups based on the ischemia time: [0–8], [9–13] and [14–29] minutes. The mean value for kidney function was an eGFR (mL/min) of 73.9 before and 66.8 at a 12-month post-surgery. We found no significant correlation between ischemia time and renal function. Noticeably, none of the patients had ischemia time greater than 30 min.

Conclusion

In this cohort, the duration of ischemia time was not associated with differences in renal affection neither on short term nor long term parameters if the ischemia time was kept below 30 min.

Keywords:

• Renal cancer
• partial nephrectomy
• ischemia time
• kidney cancer
• nephrectomy
• rcc
• renal cell carcinoma

Disclosure statement

No potential conflict of interest was reported by the author(s).