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Abstract
Thirteen compounds (flavonoids, phenolic acids and sterols) were isolated from the aerial parts of Hypericum tomentosum L. Their structures were established on the basis of physical and spectroscopic analysis, and by comparison with the literature data. In vivo and in vitro protective effect of the butanolic extract of H. tomentosum (BEHT) against acute oxidative stress induced by a single dose of 20 mg/kg epirubicin (an anticancer drug) was evaluated in female Wistar rat using kidney and heart cytosolic fraction. Scavenging effect of BEHT, lipid peroxidation (MDA), glutathione (GSH) concentration and Catalase activity were measured. BEHT extract restored the renal and heart functions and clearly shows a protective effect against epirubicin-induced oxidative stress.