THE EFFECTS OF BISOPROLOLA SELECTIVE β₁-BLOCKERON GLUCOSE METABOLISM BY LONG-TERM ADMINISTRATION IN ESSENTIAL HYPERTENSION

Abstract

Bisoprolola β₁-selective β-blockerwas administered to 13 patients with mild to moderate essential hypertension once daily at doses of 5–10 mg for 24 weeksand its long-term effects on blood pressure and glucose metabolism were investigated.

The systolicdiastolic and mean blood pressures were significantly reduced. At the end of the treatment periodthe blood glucose level and hemoglobin A₁c were not significantly different from those at baseline. In the glucose tolerance test at the end of the treatment periodthe blood glucose and plasma insulin levels after a glucose load of 75 g were not significantly different at any time pointand the sums of each were not significantly different from their baseline levels.

Based on these resultsbisoprolol appears to be a β₁-selective β-blocker possessing a satisfactory hypotensive effect without any adverse effects on glucose metabolism for long-term useand is therefore a safe and useful drug for the treatment of essential hypertension.

• Bisoprolol
• β₁-selective β-blocker
• Blood glucose
• Glucose tolerance test