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Clinical and Experimental Hypertension Volume 24, 2002 - Issue 7-8
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HYPERHOMOCYST(E)INEMIA: A RISK FACTOR FOR CEREBROVASCULAR DISEASE

Lucilla Parnetti Neuroscience Department, University of Perugia, Perugia, Italy
,
Valeria Caso Neuroscience Department, University of Perugia, Perugia, Italy
,
Serena Amici Neuroscience Department, University of Perugia, Perugia, Italy
,
Alessia Lanari Neuroscience Department, University of Perugia, Perugia, Italy
,
Virgilio Gallai Neuroscience Department, University of Perugia, Perugia, Italy
&
Teodoro Bottiglieri Institute of Metabolic Disease, Baylor University Medical Center, Dallas, Texas, U.S.A.
Pages 501-509 | Published online: 10 Aug 2002
 
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Abstract

Many case-control and cohort studies have identified a strong, independent and dose-related association between moderate hyperhomocyst(e)inemia and atherosclerotic vascular disease, with respect to the pathogenetic link between hyperhomocyst(e)inemia and stroke, the possible role in inducing an endothelial wall damage deserves special attention. Some prospective cohort studies have failed to demonstrate a positive association between elevated homocyst(e)ine (Hcy) levels and stroke. Further studies are needed, in order to better characterize the association between Hcy concentrations and risk of stroke.

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