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Journal of Toxicology: Clinical Toxicology Volume 39, 2001 - Issue 6
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Research Article

Severe Reversible Bone Marrow Suppression Induced by Selaginella doederleinii

Kun-Ying Pan Department of Internal Medicine, Poison Center, Chang Gung University, Taipei, Taiwan
,
Dr. Ja-Liang Lin Department of Internal Medicine, Poison Center, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei, Taiwan; Department of Internal Medicine, Poison Center, Chang Gung University, Taipei, Taiwan
&
Jen-Shi Chen Division of Hemotology and Oncology, Department of Internal Medicine, Chang Gung University, Taipei, Taiwan
Pages 637-639 | Published online: 31 Oct 2001
 
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Abstract

Case Report: We report a 52-year-old female patient with cholangiocarcinoma who developed severe bone marrow suppression after taking Selaginella doederleinii as an alternative anticancer treatment. She developed severe pancytopenia with initial presentations of skin ecchymosis, itching, and gum bleeding 2 weeks after taking Selaginella doederleinii daily. Bone marrow smear and biopsy showed severe hypocellularity with no malignant cell infiltration. Approximately 1 week after stopping Selaginella doederleinii, her hemogram returned to previous levels. Selaginella doederleinii, a popular anticancer herb, may contain an as yet unidentified substance that contributes to reversible bone marrow suppression.

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