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Abstract
Estrogen receptor (ER)-β may play a significant role in estrogen action in several human tissues. Estrogen receptor β may act as a transdominant repressor of ERα transcriptional activity trough heterodimers form. Estrogen receptor messenger RNA (mRNA) variants also may be involved in various diseases, including endometrial cancer. The absence of estrogen receptors has often correlated with poor prognosis of endometrial tumors. The objective of the study was to determine the number of mRNA ERβΔ6 and (wtERβ) in 1 µg total RNA obtained from tissues of normal, hyperplastic endometrium, and endometrial adenocarcinoma. This study was designed to evaluate possible differences in the ERβΔ6 and wtERβ messenger RNA (mRNA) level in the normal, hyperplastic endometrium, and endometrial endometrioid adenocarcinoma (G1, G2 morphological degree). Adenocarcinoma showed significantly lower ERβΔ6 mRNA level than proliferative (p = 0.032) and secretory (p = 0.01) endometrium. A decrease of mRNA wtERβ in endometrial adenocarcinoma (p = 0.006) also was observed.