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Cancer Investigation Volume 22, 2004 - Issue 2
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Brief Clinical Report

ANNA-2: An Antibody Associated with Paraneoplastic Opsoclonus in a Patient with Large-Cell Carcinoma of the Lung with Neuroendocrine Features—Correlation of Clinical Improvement with Tumor Response

Rodrigo Erlich Department of Oncology, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, Maryland, 21224, USA
, M.D.,
Candis Morrison Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PennsylvaniaUSA
, C.R.N.P. , Ph.D.,
Bong Kim Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PennsylvaniaUSA
, M.D.,
Mark R. Gilbert Division of Neuro-Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TexasUSA
, M.D. &
Saadah Alrajab Department of Medicine, Greater Baltimore Medical Center, Baltimore, MarylandUSA
, M.D.
Pages 257-261 | Published online: 24 Aug 2009
 
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Abstract

This report describes a case of large-cell lung carcinoma with neuroendocrine features, presenting with the full clinical picture of paraneoplastic opsoclonus–myoclonus syndrome. The patient had an unexpectedly dramatic resolution of the neurologic dysfunction after receiving antineoplastic treatment. Symptom improvement paralleled a progressive decline of serum ANNA-2 antibody titers to undetectable levels.

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