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| Abbreviations | ||
| A | = | area (cm2) |
| C | = | concentration in receptor cell at time t |
| Cm | = | maximal concentration in receptor cell |
| Csc | = | concentration in outermost layer of the stratum corneum |
| Cv | = | concentration in vehicle |
| D | = | diffusion coefficient (cm2/h) |
| Dm | = | minimum diffusion coefficient attainable by powerfully H-bonding molecule |
| Do | = | diffusion coefficient of infinitely small, non-H-bonding molecule |
| h | = | pathlength of diffusion (cm) |
| Js | = | flux (mol/cm2/h) at the steady state |
| K | = | rate of desorption/rate of adsorption at an interface |
| Ka/b | = | partition coefficient in phases a, b |
| kp | = | permeability coefficient (cm/h) |
| PC | = | principal component |
| PCA | = | principal component analysis |
| r2 | = | coefficient of determination adjusted for degrees of freedom |
| RCx | = | retardation coefficient of H-bonding group x |
| SC | = | stratum corneum |
| V | = | intrinsic molar volume (dm3/mol) |
| α | = | scaled H-bonding donor (acid) potential |
| β | = | scaled H-bonding acceptor (base) potential |
| δ | = | Hildebrand solubility parameter |
| π* | = | dipole moment/polarizability |
Notes
*Reprinted from Percutaneous Adsorption, 3rd Ed.; Bronaugh, R.L., Maibach, H.I., Eds.; Marcel Dekker, Inc.: New York, 1999; 177–192.