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Drug Development and Industrial Pharmacy Volume 25, 1999 - Issue 12
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Research Article

Study of Solubility of Steroids in Hydrofluoroalkane Propellants

Robert O. Williams III College of Pharmacy, University of Texas at Austin, Austin, TX, 78712-1074, U.S.A.; College of Pharmacy (Mailstop A1920), University of Texas at Austin, Austin, TX, 78712-1074, U.S.A.
,
True L. Rogers College of Pharmacy, University of Texas at Austin, Austin, TX, 78712-1074, U.S.A.
&
Jie Liu
Pages 1227-1234 | Published online: 12 Jul 1999
 
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Abstract

The solubility of prednisone, hydrocortisone 21–acetate, hydrocortisone, dexamethasone, betamethasone 17–valerate, and danazol in hydrofluoroalkane (HFA) 134a and HFA 227 was determined at 5°C and 25°C. It was found that the solubility of steroid in HFA propellants was related to the melting point and the lipophilicity of the steroid. The solubility of the steroids in the binary system of HFA propellants and ethanol also was investigated in the study. Ethanol significantly increased the solubility of the steroids in HFA propellant. The magnitude of increase was related to the solubility of the corresponding steroid in ethanol alone.

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